I'd fold pre as that 4x raise is hard to handle and hard to range. We don't want to 3bet it since he's doing it in ep and we'd have to put A LOT of chips to do so. Neither can we flat since there's only about 10x the raise to win IF we manage to hit the set AND double up, some math:

P(flop set)= 1 - P(miss set) = 1 - (48/50 x 47/49 x 46/48)= 0,1176 ~ 12%

Even if the blinds are 3betting a really tight range against this bet they're still doing it around 3% (jj+ and AK) meaning that since there are two of them you won't even get to see the flop 6% of the time.

After this you need to range up EP villain and estimate how often you will get his stack if you actually hit your set:

If his range is something like 1010+ Ak+ AQs (just for the sake of argument) the math gets real annoying. Just to demonstrate the though let's say you alway hit your set on a LOW flop where he's always doubling you up with all his pair type hands.
His range consists of 16 combinations of AK (4 aces, 4 kings), 4 combinations of AQs and 30 combinations of pairs (4 x 3 / 2 combos x 5 pairs) meaning he'll double you up with:

#pair combos / tot #combos = 30/50 = 60%

Now we have all the numbers we need to see what we need in our stack. We start by thinking he's gonna double us up 100% of the times =) and then we go:

"oops, we might not see the flop often since the blinds may 3bet 6% of the times":

100% x 0,94 = 94%

"fine, we'll double up 94% of the times ^_^...oh wait, we don't hit our set much":

94% x 0,12 = 11,28%

"meh, 11,28% seems a bit low, I liked 100 better <.< oh wait, he doesn't double us up more than 60% of those times":

11,28 x 0,6 = 6,8%

meaning that you'll need at least

100%/6,8% =
14,7 x his raise in your stack to make it a breakeven play, even more to show a decent profit.

On the flop I go "oops, I shouldn't have called pre, let's fold since he's gonna have us beat 60% of the times" and then I fold.

Hope this helped you some

Edit: Some final thoughts: probability of blinds 3betting is in fact

1 - P(no 3bet) = 1 - 0,97^2 but I'm too lazy to change that.

Also, pot odds wise we need a bit less chips to setmine profitably since he's gonna have air some of the time when we don't flop a set (AK, AQ type hands) but in reality we'll just be cbet off off those spots.

Ranges need some adjustment, I assigned him a really tight range but in reality I think his range is more polarized and contain a bit of air to. The 4x from EP play is fairly new but you really start to see it more and more